609-258-2711, Steve Elwood Peroxide formation can be initiated by exposure to air, self-polymerization, or solvent impurities. (a)Institute for Environmental Health Inc. dba IEH Warren Analytical Laboratory at 650 O Street, Greeley, CO: On and preceding 3/11/15, the employer did not furnish employment and a place of employment which were free from recognized hazards that were causing or likely to cause death or serious physical harm to employees, in that employees were exposed to a fire hazard. 200 Constitution Ave NW Do not store ethers at or below the temperature at which the peroxide freezes or the solution precipitates. Proper labeling, tracking, and disposal are all components of a proper program, as well as training employees. The flashpoints of toluene and methanol are approximately 16 degrees Celsius, while the flashpoint of petroleum ether is -18 degrees Celsius. Princeton, NJ 08540ehs@princeton.edu609-258-5294, © 2021 The Trustees of Princeton University, Office of Environmental Health and Safety, Hazard Identification and Risk Assessment, Laboratory Access and Training Recommendations, Laboratory Equipment and Engineering Controls, SHIELD - Safety, Health, Inspection and Equipment Logistics Database, Administration of Biological and Chemical Hazards to Animals, Recombinant and Synthetic Nucleic Acid Molecules, Shipping and Receiving Biological Material, X-Ray Machines & Other Radiation-Producing Equipment, Personal Protective Equipment (PPE) for Construction, Resumption of On-Campus Operations Planning. Ideally, purchases of peroxidizable chemicals should be restricted to ensure that these chemicals are used up completely before peroxides can form. Here is a list of some of the most common peroxide-forming chemicals (see J. Chem. Compounds containing allylic hydrogens, includ… 800-321-6742 (OSHA) TTY Ethers and acetals with an Α-hydrogen, especially cyclic ethers and those containing primary and secondary alkyl groups 2. Peroxide Forming Chemicals ... d These chemicals easily form peroxides and should probably be considered under Part B. e OSHA - regulated carcinogen. Peroxide Forming Compounds. Record testing dates and test results. Remove inhibitors using column purification. [Note: The pure compound is a crystalline solid below 12°F. DELETE instance (c) (c)Institute for Environmental Health Inc. dba IEH Warren Analytical Laboratory at 650 O Street, Greeley, CO: On and preceding 3/11/15, the employer did not furnish employment and a place of employment which were free from recognized hazards that were causing or likely to cause death or serious physical harm to employees, in that employees were exposed to a fire hazard. Expired containers of peroxide- forming chemicals must be immediately disposed of properly through EHS. The tendency to form peroxides by most of these materials is greatly increased by evaporation or distillation. This condition exposed employees to fire hazards. More robust PPE and engineering controls may be required when working with peroxides and peroxide forming compounds. This condition exposed employees to fire hazards. Visually inspect all containers before opening for crystal formation or cloudiness. f Extremely reactive and unstable compound. Washington, DC 20210 OSH ACT of 1970 Section (5)(a)(1): The employer did not furnish employment and a place of employment which were free from recognized hazards that were causing or likely to cause death or serious physical harm to employees in that employees were exposed were exposed to fire hazards. Vials containing methanol and toluene and flasks containing petroleum ether were placed into VWR model 1650D drying ovens in the wet lab. Users must request such authorization from the sponsor of the linked Web site. This condition exposed employees to fire hazards. Peroxide-forming compounds contain a reactive hydrogen atom that is “activated” by adjacent structural components. Choose the size container that will ensure use of the entire contents within a short period of time. Occupational Safety and Health Administration, Severe Storm and Flood Recovery Assistance. Researchers should purchase no more material than is needed to complete an experiment within the chemical's safe shelf life. The following tables list common peroxide-forming chemicals. Peroxide formation can be initiated by exposure to air, self-polymerization, or solvent impurities. (d)Institute for Environmental Health Inc. dba IEH Warren Analytical Laboratory at 650 O Street, Greeley, CO: On and preceding 3/11/15, the employer did not furnish employment and a place of employment which were free from recognized hazards that were causing or likely to cause death or serious physical harm to employees, in that employees were exposed to a fire or explosion hazard. Peroxide-forming chemicals are a class of compounds that have the ability to form shock-sensitive explosive peroxide crystals. www.OSHA.gov. The diethyl ether had an expiration date of May 31, 2009, while the tetrahydrofuran had an expiration date of April 19, 2000. Many of the organic solvents commonly used in laboratories at Weill Cornell Medicine (WCM) are peroxide formers. Dioxanes. Peroxide-forming materials are chemicals that react with air, moisture, or impurities to form peroxides. Peroxide-forming chemicals should be stored in their original manufacturer’s container whenever possible. Peroxide-forming labels to record testing date and results are available here: Chemical Label Request. Employees used diethyl ether and tetrahydrofuran at the facility. If either of these conditions are observed, DO NOT OPEN and ALERT EHS. diethyl ether, tetrahydrofuran, dioxane, etc.) Compounds containing benzylic hydrogens 3. The employer did not ensure that the peroxide forming liquids were disposed by the expiration date and no more than one year past opening the container. High-strength hydrogen peroxide, Hydrogen dioxide, Hydrogen peroxide (aqueous), Hydroperoxide, Peroxide Colorless liquid with a slightly sharp odor. www.OSHA.gov, Occupational Safety and Health Administration ... Cal/OSHA requires that manufacturers provide labels with the following information: • contents of the container • physical and health hazard information Test strips are available from the EHS Department, Any chemical that tests greater than 100ppm should be disposed of, please contact EHS for assistance. Please contact EHS for a full risk assessment. Ed 1970 , 47(3) , A176; subscription required to … This guide describes methods for safely storing, using, and disposing of time-sensitive chemicals, which are any chemicals or chemical products that develop additional hazards upon prolonged storage. Both chemicals are Class B peroxide forming liquids. Acetaldehyde. Interestingly, peroxides can form prior to the stipulated expiration or shelf-life of the co… The flammable liquids were not stored in flammable liquid storage cabinets, safety cans, or inside storage rooms. Benzyl alcohol. 6.3 Peroxide Forming Compounds and Reactives. Peroxide formers, or peroxidizables, are materials which react with oxygen to form peroxides which can explode from impact, heat, or friction. In order for the Chemical Hygiene Officer to effectively implement a peroxide former program, they need to be made aware of the peroxide forming chemicals before they are received. Associate Director for Laboratory Safety Diethyl ether (ether) 2-Pentanol. * Never open or test containers of unknown origin or age, or those that have evidence of peroxide formation, ‡ Unless otherwise specified on the bottle. The peroxy group is chemically unstable, and can decompose with varying degrees of … Often used in an aqueous solution.] Peroxide-Forming Chemicals Overview. Peroxides can occur in virtually any kind of organic chemical, however, certain chemicals are particularly prone to peroxide formation and pose special hazards. This condition exposed employees to fire or explosion hazards. Some SDSs may include the European hazard classification “May Form Organic Peroxides” under “hazards not otherwise classified” at the bottom of Section 2 of the SDS. Peroxide-forming chemicals (PFs) are chemicals that can “auto-oxidize” with atmospheric oxygen under ambient conditions to form organic peroxides (contains an -O–O- bond). The following recommendations should be followed to control the hazards of peroxides. Many of the organic solvents commonly used in laboratories have the potential to form explosive peroxide crystals. Do not use metal spatulas or magnetic stirring bars (which may leach out iron) with peroxide forming compounds, since contamination with metals can lead to explosive decomposition. These materials are particularly dangerous because they can be hazardous even if never opened. Always purchase solvents that are inhibited against peroxide formation. To generalize, the kinds of chemicals that can form peroxides include aldehydes, ethers, and numerous unsaturated hydrocarbon compounds (i.e. Never distill peroxide forming chemicals to dryness. Visually or chemically check for peroxides of any opened containers before use. The tendency to form peroxides by most of these materials is greatly increased by evaporation or distillation. 1. The diethyl ether had an expiration date of May 31, 2009, while the tetrahydrofuran had an expiration date of April 19, 2000. To request additional copies of the poster in various sizes, please contact EHS. Peroxides may detonate with extreme violence when concentrated by evaporation or distillation, when combined with other compounds, or when disturbed by unusual heat, shock or friction. Refer to TABLE 2 for a listing of each peroxidizable classification. Form explosive peroxides when distilled, evaporated or otherwise concentrated. 200 Constitution Ave NW In addition, peroxide formers should be dated upon receipt, again dated upon opening, and stored away from heat and light with tight fitting, nonmetal lids. The refrigerator was not designed to contain flammable or combustible liquids. List A: Chemicals that may form explosive levels of peroxides without concentration by evaporation or distillation. Avoid storing chemicals on countertops or in fume hoods except those currently in use. Follow the same basic handling procedures as for flammable materials. The drying ovens were not designed to contain flammable or combustible liquids. Many of these peroxide-forming chemicals are commonly used organic solvents, but when they are allowed to form peroxides, they can become more shock-sensitive than TNT. Users of these chemicals should pay special attention to when the chemical was received, when the chemical was opened, and when the chemical should be tested for peroxide concentration. The employer did not ensure that the peroxide forming liquids were disposed by the expiration date and no more than one year past opening the container. For example, rotary evaporation of an etheryl solvent such as tetrahydrofuran or diethyl ether couls pose a significant risk. 609-258-6271, Environmental Health and Safety Peroxide Forming Chemicals Certain chemicals can form dangerous peroxides on exposure to air and light. Peroxide-forming chemicals (PFCs) are chemicals that can “auto-oxidize” with atmospheric oxygen under ambient conditions to form organic peroxides (contains an -O–O- bond). 5.11 Peroxide Forming Chemicals 34 Page. hydrocarbon compounds having double or triple bonds). Both chemicals are Class B peroxide forming liquids. Peroxide forming chemicals should be used or disposed of prior to the expiration date. General Information: EHS SOP (EHS-0042) is located on the EHS Website. Peroxide-forming materials are chemicals that react with air, moisture, or impurities to form peroxides. Peroxide-forming compounds are among the most hazardous substances commonly handled in laboratories. TTY Peroxide-forming chemicals are a class of compounds that have the ability to 2.form shock-sensitive explosive peroxide crystals. MSU Chemical Hygiene Plan 3.6.6 OSHA Standard 1910.1450 App A. NPFA 45 9.2.3.4; Corrective actions: Test peroxide formers periodically. Testing Labels for Peroxide Forming Chemicals: 2"x4" 1"x2-5/8" For more information: Chemical Incompatibility Chart; Chemical Reactivity Worksheet - Excellent web-based database; Chemical Reactivity Hazards - OSHA; Additional resources for chemicals that exhibit explosive properties, peroxide formation and container pressurization hazards. Diethylene glycol dimethyl ether (diglyme) 4-Methyl-2-pentanol. Care must be taken when handling inorganic or organic peroxides, since they tend to be unstable and can, depending on the compound, decompose violently. Certain chemicals can form dangerous peroxides on exposure to air and light. Diethyl ether and tetrahydrofuran are two of the more common peroxide-forming chemicals used today. Since they are sometimes packaged in an atmosphere of air, peroxides can form even though the containers have not been opened. Abatement Note: Abatement may be achieved for instances (a), (b), and (c) by compliance with National Fire Protection Association (NFPA) 45 "Standard on Fire Protection for Laboratories Using Chemicals". Many chemicals can undergo autooxidation to form explosive peroxides (see lists below). Refer to TABLE 1 for testing or disposal frequency. 2 3 Introduction The safe storage of hazardous chemicals is an essential part of an environmental, health, and safety program. Sigma-Aldrich: Peroxide Forming Solvents University of Pittsburgh Safe Handling of Peroxide Forming Chemicals Pyrophorics. Note that the ability to form peroxides is a hazard category that is NOT classified under GHS. Minimize peroxide formation in ethers by storing in tightly sealed containers placed in a cool place in the absence of light. Thank you for visiting our site. This requires careful experiment planning on behalf of researchers. Xylene and 1,1,3,3-tetraethoxy propane, flammable liquids, were stored in a Frigidaire model F44C18SHWO refrigerator in the wet lab. The Department of Labor also cannot authorize the use of copyrighted materials contained in linked Web sites. Organic peroxides are extremely sensitive to shock, sparks, heat, friction, impact, and light. It is the double oxygen of the "peroxy" group that makes organic peroxides both useful and hazardous. Time-sensitive chemicals may include: Peroxide Formers: Oxygenated organic compounds that react with atmospheric oxygen to form explosive peroxides. Certain chemicals can form dangerous peroxides on exposure to air and light. Ceramic, Teflon or wooden spatulas and stirring blades are usually safe to use. This generic chemical safety guidance describes basic prudent safety practice for handling this chemical in research labs. Label containers with the date received, the date first opened and the date for disposal as recommended by the supplier. Acetal. Peroxides may detonate with extreme violence when concentrated by evaporation or distillation, when combined with other compounds, or when disturbed by unusual heat, shock or friction. Before distilling any peroxide forming chemicals, always test the chemical first with peroxide test strips to ensure there are no peroxides present. Occupational Safety and Health Administration Please click the button below to continue. Employees used flammable liquids, including ethanol, methanol, toluene, diethyl ether, and petroleum ether in the wet lab and fat lab. 262 Alexander Street Examples in this group include allyl compounds, haloalkenes, dienes, monomeric vinyl compounds, vinylacetylenes, unsaturated cyclic hydrocarbons like tetrahydronaphthalene or dicyclopentadiene. If inhibitor free solvent must be purchased, follow all documented instructions for use and always purge with notrogen before storage. Formation of peroxides is accelerated in opened and partially emptied containers. All test results should be recorded directly on the container. The vials, flasks, and flammable liquids were heated to 100 degrees Celsius. Organic peroxides are extremely sensitive to shock, sparks, heat, friction, impact, and light. Leave at least 10-20% still bottoms to help prevent possible explosions. Abatement Note: Abatement may be achieved for instance (d) by compliance with manufacturer specifications for use and storage of Class B peroxide forming chemicals. Determine if the chemical in question poses a risk of forming peroxides. can form explosive peroxides through a relatively slow oxidation process in the presence of air and light. These are a group of chemicals that have an oxygen-to-oxygen bond (R–O–O–R). Peroxide-forming chemicals shall be stored in sealed, air-impermeable, light-resistant containers and should be kept away from light (light can initiate peroxide formation). The OSHA Laboratory standard defines a CHP as “a written program developed and implemented by the employer which sets forth procedures, equipment, personal protective equipment and work practices that are capable of protecting employees from the health hazards presented by hazardous chemicals used in that particular workplace.” (29 CFR 1910.1450(b)). Reactive hydrogen atoms are most often found on the following compounds: 1. UCLA: Procedures for Safe Use of Pyrophoric Solids Yale Policy on Pyrophoric Chemicals Nanomaterials. (b)Institute for Environmental Health Inc. dba IEH Warren Analytical Laboratory at 650 O Street, Greeley, CO: On and preceding 3/11/15, the employer did not furnish employment and a place of employment which were free from recognized hazards that were causing or likely to cause death or serious physical harm to employees, in that employees were exposed to a fire hazard. Do not concentrate solutions that may contain peroxides. 800-321-6742 (OSHA) Peroxide Forming Chemicals no need for storage. If extenuating circumstances exist for keeping the chemical, routine testing must be performed. Peroxide Formers. Program Manager - Chemical Safety Several commonly used solvents (e.g. Washington, DC 20210 Inventory all chemical storage at least twice a year. Quantities of flammable liquids needed in excess of daily use were stored in the labs. For more information, refer to the Peroxide-Forming Chemicals informational poster. Read more about First-Aid for purposes of OSHA recordkeeping Peroxide-Forming Chemicals This factsheet outlines procedures for the safe use, storage and testing of peroxide-forming chemicals. An organic peroxide is a carbon-based compound containing a “peroxy” group (two oxygen atoms joined together -O-O-). Stanley Howell NIOSH Guidance and Publications on … The Department of Labor does not endorse, takes no responsibility for, and exercises no control over the linked organization or its views, or contents, nor does it vouch for the accuracy or accessibility of the information contained on the destination server. The flammable liquids were stored in fumehoods, fumehood cabinets, benchtops, refrigerators, and open shelving. 6.3 Peroxide Forming Compounds and Reactives. 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